A work coordinated by dr. Antonio Recchiuti from the laboratory of Molecular Medicine directed by prof. Mario Romano shows that resolvin D1 and D2 reduce the inflammatory response of cystic fibrosis macrophages to SARS-CoV-2.

Resolvins (Rv) are endogenous lipid autacoids that mediate resolution of inflammation and bacterial infections. Their roles in SARS-CoV-2 and COVID-19 are of considerable interest in the context of cystic fibrosis given the paucity of data regarding the effect of this virus on immune cells from individuals with this genetic disease.

In this work published as a preprint Dr. Antonio Recchiuti and his group demonstrate that SARS-CoV-2 initiates the biosynthesis of resolvins that have regulatory actions on the inflammatory responses of macrophages. These results contribute towards understanding the pathophysiological mechanisms of SARS-Cov2 infection and developing therapeutic options for COVID-19.

Resolvin D1 and D2 reduce SARS-Cov-2-induced inflammation in cystic fibrosis macrophages

Antonio Recchiuti, Sara Patruno, Domenico Mattoscio, Elisa Isopi, Antonella Pomilio, Alessia Lamolinara, Manuela Iezzi, Romina Pecce, Mario Romano

bioRxiv 2020.08.28.255463; doi: https://doi.org/10.1101/2020.08.28.255463