Published in Journal Muscle Research Cell Motility an invited review from the Laboratory of Physiology and Physiopathology of Striated Muscles directed by Prof. Feliciano Protasi.

Title: Calcium entry units (CEUs): perspectives in skeletal muscle function and disease.

Authors: Feliciano Protasi, Laura Pietrangelo, and Simona Boncompagni.

This work contains a brief overview of a project running in Protasi’s lab at CAST since 2013. This venture led to 3 main publications (Scientific Reports 2017, e-Life 2019, and Journal of General Physiology 2020) and allowed the controversial discovery of new organelles (named by the authors of this article Calcium Entry Units, CEUs) proposed as putative sites for communication of proteins involved in Store-Operated Calcium Entry (SOCE). SOCE, a mechanism that allows to retrieve extracellular calcium, has been proposed to be important to limit muscle fatigue during repetitive stimulation.